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Zofran

Zofran - antiemetic drug. Has strong antiemetic action. Blocks processing of the gag reflex. It is used for the elimination and prevention of vomiting and nausea caused by chemotherapy or radiotherapy that is toxic to living cells, as well as vomiting and nausea in the postoperative period.

Indications:

For those who buy Zofran below is information about its indications for use.

Prevention and treatment of nausea and vomiting for antitumor cytotoxic (chemotherapy) and radiation therapy (radiotherapy) cancer and the postoperative period.

Irradiation of the entire body surface, the partial or single high-daily irradiation of the abdomen. The initial and repeat courses of chemotherapy.

Severe reactions to chemotherapy.

Warning retarded (delayed) nausea and vomiting.

Prevention and reduction of postoperative arisen postoperative nausea and vomiting.

Zofran is often used in combination with cisplatin and 5-fluorouracil, carboplatin, etoposide, tseftizidimom, cyclophosphamide, doxorubicin, dexamethasone.

If you buy Zofran online without prescription, you should know the dosage recommendations and administration methods.

For the prevention of nausea and vomiting during cytostatic therapy for adults the dosing regimen is established depending on the severity of vomiting in response to a cytostatic therapy.

The daily dose usually ranges from 8 (single dose) to 32 mg (daily dose) in the form of tablets, syrups, suppositories or injections. In children, the daily dose of 8 mg - 4 mg 2 times a day. Dosage and method of administration produce individually.

When chemotherapy or radiotherapy, accompanied by the appearance of vomiting, the drug is injected into the / jet slowly in a dose of 8 mg immediately before treatment. You can also take the drug orally at a dose of 8 mg 1-2 hours before the start of therapy and then another 8 mg every 12 h after initiation of therapy.

Adults with highly emetocathartic chemotherapy - may be 3 types of primary introduction:

I - single dose of 8 mg / slow just before the start of the course;

II - initially 8 mg / slow just before treatment, followed by 8 mg / slow 2 more times at intervals of 2-4 hours, or 1 mg / h / drip for 24 hours;

III - single 32 mg, dissolved in 50-100 ml of saline infusion for at least 15 minutes, just before the start of the course. May also conduct continuous 24-hour infusion at 1 mg / h.

When choosing a dosing regimen should take into account the severity of vomiting. In very severe vomiting during chemotherapy reaction efficiency Zofran can be enhanced by a single i / v administration of GCS (eg, dexamethasone 20 mg) prior to chemotherapy.

Adults and adolescents 12 years and older can enter infusion over 15 minutes - 32 mg once daily for 30 minutes before the start of the course, or 0.15 mg / kg 3 times - 30 minutes before chemotherapy and after 4 and 8 hours.

For the prevention of delayed emesis occurring after the first 24 h from the start of chemo-or radiotherapy (as in the strong, and in less severe vomiting) is recommended to continue taking this medication by mouth with 8 mg 2 times / day or 16 mg rectally 1 per day, Within 5 days after chemotherapy.

Children from 4 to 12 years in emetocathartic chemotherapy may be two modes of the original introduction:

I - once in the / 5 mg/m2 just before the start of the course, then 4 mg PO 12 hours,

II - to 4 mg orally 3 times for 30 minutes before the course starts, then after 4 and 8 h.

Recommend further treatment by oral administration of 4 mg 2 times / day for 5 days.

For the prevention of postoperative nausea and vomiting adult drug is administered to 4 mg / m or / jet slowly at the beginning of a general anesthetic or taken orally to 16 mg for 1 h before general anesthesia. To reduce nausea and vomiting occurred recommend / m or slow I / O of the drug in a single dose of 4 mg.

Children older than 2 years to prevent postoperative nausea and vomiting during anesthesia is administered Zofran only in / slow in a single dose of 0.1 mg / kg (maximum dose - 4 mg) before or after induction of anesthesia. To reduce the arising of postoperative nausea and vomiting is recommended to slow / in a single dose of 0.1 mg / kg (maximum dose - 4 mg). V / m in the same area of the body of Zofran may be administered simultaneously at a dose not exceeding 4 mg.

Elderly patients correct dosing regimen is not required.

Patients with impaired renal function correct dosing regimen is not required.

Patients with impaired liver function should be to reduce the dose to 8 mg / day.

We highly recommend you to read information below about consequences of overdose if you are going to buy Zofran online.

In cases of alleged overdose symptomatic treatment is shown, we do not recommend you to buy Zofran.

For those who buy Zofran, below is information about its contraindications.

Hypersensitivity to the drug.

Pregnancy (especially the first 3 months).

Children age: up to 2 years in the case of anesthesia, up to 4 years - during chemotherapy, the whole age group - Radiation therapy and for use of suppositories.

Caution - liver failure, surgery for abdominal organs, lactation (at the time of treatment stop feeding).

Below is the information about possible side effects, please read it if you came here to buy Zofran online.

The nervous system: Headache, dizziness, visual disturbances (blurred, accommodation disorders), CNS depression, paresthesia, weakness, seizures, extrapyramidal symptoms;

Part of the digestive system: Constipation, diarrhea, dry mouth, hiccups, transient increase in AST and ALT, liver failure (especially against the background of hepatotoxic antiblastomic therapy and antibiotics);

Cardio-vascular system: tachycardia or bradycardia, hypotension, syncope, chest pain (anginal type), violations of the ECG (hypokalemia), including blockade of II degree, feeling a rush of blood to the face, feeling the heat, feeling the heat.

Allergic reactions (urticaria, bronchospasm, angioedema, anaphylaxis);

Redness and burning at the injection site, burning in the anus and rectum (suppositories).

The drug cannot divorce the other infusion solutions. Not recommended to enter into the same syringe with other drugs. Zofran in the form of injectable solution should not be administered in the same syringe, or through the same intravenous line through which other drugs were administered.

Rules for the preparation and administration of infusion solution:

Infusion solution should be prepared immediately before use. If necessary, a ready infusion solution can be stored prior to use for a maximum of 24 hours at 2-8 ° C. During the infusion of light protection is not required, diluted injection solution remains stable for at least 24 h under natural light or normal light.

Injectable forms are bred only recommended solutions. At a dilution of the solution for injection can be applied following infusion solutions are compatible with Zofran: an infusion of 0.9% sodium chloride solution, 5% glucose infusion solution (dextrose), 10% mannitol infusion solution, Ringer's solution infusion, 0.3% infusion solution of potassium chloride solution.

Renal impairment, as well as the elderly do not need to correct dosing regimen.

Patients who had previously allergic reactions to other selective antagonist’s 5NT3 receptors have an increased risk of development against the background of Zofran.

Zofran may slow down the motility of the colon; in connection with his appointment than patients with signs of subacute intestinal obstruction require special monitoring.